Collagen Antibody-Induced Arthritis (CAIA) has been generally utilized starting around 1998 when 4-clone mixed drink (Arthrogen-CIA arthritogenic monoclonal antibodies) units originally showed up.
To actuate steady joint inflammation all the more successfully in different mouse strains including CAIA low responder C57BL/6 mice, and an assortment of unusual knockout and transgenic mice with C57BL/6 (H-2b) or 129/Sv (H-2b) foundations, another 5-clone mixed drink units have been created by adding another clone to the 4-clone mixed drink.
The new 5-Clone CIAA creates quicker results: Typically serious joint pain is incited inside 24-48 hours rather than the a month expected to initiate CIA after inoculation with type II collagen. Not at all like the first CIA model, which requires a confined MHC haplotype, the new 5-Clone CAIA model is extensively pertinent and can prompt joint pain in practically all kinds of mice, including CIA-safe, T-cell lacking, quality knockout, and transgenic mice.
Usefully the new 5-Clone units offer phenomenal consistency meaning the seriousness of joint inflammation incited now straightforwardly connects to the portion of monoclonal immune response mixed drink, and more extreme and reliable joint inflammation can be prompted by expanding the portion of monoclonal counter acting agent mixed drink.
Hence, this model is great for concentrating on the neurotic job of individual quality items, cytokines, as well as screening and assessing mitigating specialists without impacts of complete or deficient Freund’s adjuvant, which emphatically influences the host’s resistant framework.
Established in 1987, AMS Biotechnology (AMSBIO) is perceived today as a main organization adding to the speed increase of disclosure through the arrangement of state of the art life science innovation items and administrations for innovative work in the clinical, nourishment, beauty care products and energy businesses.
The AMSBIO range incorporates expert antibodies, peptides and recombinant proteins. Likewise the organization can draw upon top to bottom mastery in extracellular lattices to give exquisite answers for concentrating on cell motility, relocation, intrusion and expansion.
Generally recognized as specialists in cell culture, AMSBIO accomplices with clients in fitting cell frameworks to improve screening results and inevitable guess. With a scope of atomic identification reagents, and a huge Biorepository the organization can likewise give tissue DNA, RNA, protein and microarray items.
Creature models have added to amazing advances in the comprehension of various human sicknesses. As important
as creature models are, a few disadvantages do exist. One such disadvantage originates from the various wellsprings of changeability which
can influence the result of the examinations.
In this manner, a pilot study is by and large suggested for first time clients of all creature models. A concise conversation of the 2 central matters of changeability will be made sense of underneath.
1. Mouse Vendors
The hereditary foundation of mice, even in a similar strain, will fluctuate from one merchant to another and can influence how the creatures
answer different reagents, along these lines affecting the consequences of your analysis (1). Along these lines, testing creatures from various
merchants utilizing a characterized convention is suggested prior to continuing with an enormous full-scale analyze.
2. Lodging Conditions
The microorganisms greenery is vital to the strength of the creature, including the legitimate working of the safe framework (1).
Subsequently, we suggest lodging creatures in Specific Pathogen Free (SPF) conditions instead of regular circumstances
to stay away from fluctuation brought about by microorganisms.
In general, exceptional thought of these primary concerns of fluctuation will help the analyst in finishing their trials with
less jumbling results.
CAIA sidesteps the prerequisite for host’s age of autoantibodies to type II collagen, consequently can be initiated in mice that try not to have CIA-helpless MHC-haplotypes (H-2q and H-2r) like different knockout or transgenic mice.
All kinds of mice, which are typical regarding mounting a provocative reaction including supplement enactment, ought to be
defenseless to CAIA.
Arthrogen-CIA 5-Clone Cocktail Kit - 10mg | ||||
| 53010 | Chondrex | 10 mg/ml x 1 ml | 720 EUR | |
Arthrogen-CIA 5-Clone Cocktail Kit - 40mg | ||||
| 53040 | Chondrex | 10 mg/ml x 4 ml | 2781 EUR | |
Arthrogen-CIA 5-Clone Cocktail Kit - 100mg | ||||
| 53100 | Chondrex | 10 mg/ml x 10 ml | 6695 EUR | |
Rabbit Anti Human FOXO1 Monoclonal Clone CIA-6 | ||||
| IRBAHUFOXO1CIA6C100UL | Innovative research | each | 496 EUR | |
MHC Class II (I-A) mouse monoclonal antibody, clone CIa-I, PE | ||||
| AM08124RP-N | Origene Technologies GmbH | 100 µg | Ask for price | |
MHC Class II (I-A) mouse monoclonal antibody, clone CIa-I, FITC | ||||
| AM08124FC-N | Origene Technologies GmbH | 500 µg | Ask for price | |
MHC Class II (I-A) mouse monoclonal antibody, clone CIa-I, Biotin | ||||
| AM08124BT-N | Origene Technologies GmbH | 500 µg | Ask for price | |
MHC Class II (I-A) mouse monoclonal antibody, clone CIa-I, Purified | ||||
| AM08124PU-N | Origene Technologies GmbH | 500 µg | Ask for price | |
Monoclonal CIAS1 Antibody (monoclonal) (M01), Clone: 3B1 | ||||
| AMM03391G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CIAPIN1 Antibody (monoclonal) (M01), Clone: 5G8 | ||||
| AMM03390G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal GFAP Antibody (clone GA-5), Clone: GA-5 | ||||
| APG03319G | Leading Biology | 0.05mg | 580.8 EUR | |
Monoclonal NKX2-5 Antibody (monoclonal) (M01), Clone: S3 | ||||
| AMM06706G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal NKX2-5 Antibody (monoclonal) (M02), Clone: S1 | ||||
| AMM06707G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CCL5 / RANTES Antibody (clone 50013-5), Clone: 50013-5 | ||||
| AMM02131G | Leading Biology | 0.05ml | 580.8 EUR | |
Monoclonal ART3 Antibody (clone 3A2), Clone: 3A2 | ||||
| AMM01902G | Leading Biology | 0.05mg | 633.6 EUR | |
Monoclonal FTO Antibody (clone 5-2H10), Clone: 5-2H10 | ||||
| AMM04626G | Leading Biology | 0.05ml | 580.8 EUR | |
Monoclonal Antibody to 5-Lipoxygenase (5-LO) | ||||
| MAB355Hu21 | Cloud-Clone | 100ul | 246 EUR | |
Monoclonal Antibody to 5-Lipoxygenase (5-LO) | ||||
| MAB355Hu22 | Cloud-Clone | 100ul | 246 EUR | |
Monoclonal Antibody to 5-Lipoxygenase (5-LO) | ||||
| MAB355Hu23 | Cloud-Clone | 100ul | 253 EUR | |
Monoclonal Antibody to 5-Lipoxygenase (5-LO) | ||||
| MAB355Hu24 | Cloud-Clone | 100ul | 250 EUR | |
UACA Monoclonal antibody [Clone: AE-5] | ||||
| AE-5-100ug | Biologicals | 100 ug | 141.79 EUR | |
UACA Monoclonal antibody [Clone: AE-5] | ||||
| AE-5-1mg | Biologicals | 1 mg | 897.6 EUR | |
UACA Monoclonal antibody [Clone: AE-5] | ||||
| AE-5-500ug | Biologicals | 500 ug | 479.6 EUR | |
Monoclonal ARTS-1 Antibody (monoclonal) (M01), Clone: 4H8 | ||||
| AMM03275G | Leading Biology | 0.1mg | 580.8 EUR | |
Artn mouse monoclonal antibody, clone 185230 | ||||
| MO15021-500 | Origene Technologies GmbH | 500 µg | Ask for price | |
Monoclonal Antibody to Cadherin 5 (CDH5) | ||||
| MAB366Hu22 | Cloud-Clone | 100ul | 203 EUR | |
Monoclonal Antibody to Cadherin 5 (CDH5) | ||||
| MAB366Ra21 | Cloud-Clone | 100ul | 267 EUR | |
Monoclonal Antibody to Cadherin 5 (CDH5) | ||||
| MAB366Ra22 | Cloud-Clone | 100ul | 271 EUR | |
Monoclonal Antibody to Cadherin 5 (CDH5) | ||||
| MAB366Ra23 | Cloud-Clone | 100ul | 272 EUR | |
Monoclonal Antibody to Interleukin 5 (IL5) | ||||
| MAA078Bo21 | Cloud-Clone | 100ul | 279 EUR | |
Monoclonal Antibody to Interleukin 5 (IL5) | ||||
| MAA078Hu21 | Cloud-Clone | 100ul | 252 EUR | |
Monoclonal Antibody to Interleukin 5 (IL5) | ||||
| MAA078Hu22 | Cloud-Clone | 100ul | 235 EUR | |
Monoclonal Antibody to Interleukin 5 (IL5) | ||||
| MAA078Po21 | Cloud-Clone | 100ul | 279 EUR | |
Monoclonal Antibody to Interleukin 5 (IL5) | ||||
| MAA078Po22 | Cloud-Clone | 100ul | 288 EUR | |
Keratin 5 (KRT5) Monoclonal Antibody (Human) | ||||
| 4-MAA488Hu22 | Cloud-Clone |
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Monoclonal CD59 Antibody (clone MEM-43/5), Clone: MEM-43/5 | ||||
| AMM01725G | Leading Biology | 0.05mg | 580.8 EUR | |
Nephritogenic Monoclonal Antibody, Clone 114, 5 mg | ||||
| 70205 | Chondrex | 1 mg/ml x 5 ml | 3502 EUR | |
Interleukin 5 (IL5) Monoclonal Antibody (Human) | ||||
| 4-MAA078Hu22 | Cloud-Clone |
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Mfn2 mouse monoclonal antibody, clone N153/5 | ||||
| 75-173 | Origene Technologies GmbH | 100 µl | Ask for price | |
PHYH mouse monoclonal antibody, clone N210/5 | ||||
| 75-238 | Origene Technologies GmbH | 100 µl | Ask for price | |
Kcna4 mouse monoclonal antibody, clone L71/5 | ||||
| 75-316 | Origene Technologies GmbH | 100 µl | Ask for price | |
CD40 mouse monoclonal antibody, clone G28-5 | ||||
| DDX0130P-100 | Origene Technologies GmbH | 100 µg | Ask for price | |
Mfn2 mouse monoclonal antibody, clone N153/5 | ||||
| 73-173 | Origene Technologies GmbH | 5 ml | Ask for price | |
PHYH mouse monoclonal antibody, clone N210/5 | ||||
| 73-238 | Origene Technologies GmbH | 5 ml | Ask for price | |
Kcna4 mouse monoclonal antibody, clone L71/5 | ||||
| 73-316 | Origene Technologies GmbH | 5 ml | Ask for price | |
RBM17 mouse monoclonal antibody, clone N219/5 | ||||
| 75-234 | Origene Technologies GmbH | 100 µl | Ask for price | |
Cadm4 mouse monoclonal antibody, clone N244/5 | ||||
| 75-247 | Origene Technologies GmbH | 100 µl | Ask for price | |
CLCN3 mouse monoclonal antibody, clone N258/5 | ||||
| 75-259 | Origene Technologies GmbH | 100 µl | Ask for price | |
RBM17 mouse monoclonal antibody, clone N219/5 | ||||
| 73-234 | Origene Technologies GmbH | 5 ml | Ask for price | |
Cadm4 mouse monoclonal antibody, clone N244/5 | ||||
| 73-247 | Origene Technologies GmbH | 5 ml | Ask for price | |
CLCN3 mouse monoclonal antibody, clone N258/5 | ||||
| 73-259 | Origene Technologies GmbH | 5 ml | Ask for price | |
CIAPIN1 mouse monoclonal antibody,clone OTI1A2 | ||||
| TA808781 | Origene Technologies GmbH | 100 µl | Ask for price | |
CIAPIN1 mouse monoclonal antibody,clone OTI1A2 | ||||
| TA808781S | Origene Technologies GmbH | 30 µl | Ask for price | |
Keratin 5 (KRT5) Monoclonal Antibody (Human), PE | ||||
| 4-MAA488Hu22-PE | Cloud-Clone |
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Monoclonal CD11c FITC Monoclonal Antibody (Clone 3.9), Clone: 3.9 | ||||
| APR15331G | Leading Biology | 50 tests | 580.8 EUR | |
Keratin 5 (KRT5) Monoclonal Antibody (Human), APC | ||||
| 4-MAA488Hu22-APC | Cloud-Clone |
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Keratin 5 (KRT5) Monoclonal Antibody (Human), Cy3 | ||||
| 4-MAA488Hu22-Cy3 | Cloud-Clone |
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Keratin 5 (KRT5) Monoclonal Antibody (Human), HRP | ||||
| 4-MAA488Hu22-HRP | Cloud-Clone |
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Keratin 5 (KRT5) Monoclonal Antibody (Human), FITC | ||||
| 4-MAA488Hu22-FITC | Cloud-Clone |
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Monoclonal STX5 / Syntaxin 5 Antibody (clone 5A6), Clone: 5A6 | ||||
| AMM08041G | Leading Biology | 0.05mg | 633.6 EUR | |
Monoclonal CD28 FITC Monoclonal Antibody (Clone CD28.2), Clone: CD28.2 | ||||
| AMM00025G | Leading Biology | 0.05mg | 475.2 EUR | |
Cd4 rat monoclonal antibody, clone RM4-5, PE | ||||
| AM05638RP-N | Origene Technologies GmbH | 1 ml/100 Tests | Ask for price | |
Interleukin 5 (IL5) Monoclonal Antibody (Human), PE | ||||
| 4-MAA078Hu22-PE | Cloud-Clone |
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Monoclonal Cytokeratin 5 Antibody, Clone: 1E1 | ||||
| AMM05823G | Leading Biology | 0.1ml | 580.8 EUR | |
Interleukin 5 (IL5) Monoclonal Antibody (Human), APC | ||||
| 4-MAA078Hu22-APC | Cloud-Clone |
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Interleukin 5 (IL5) Monoclonal Antibody (Human), Cy3 | ||||
| 4-MAA078Hu22-Cy3 | Cloud-Clone |
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Interleukin 5 (IL5) Monoclonal Antibody (Human), HRP | ||||
| 4-MAA078Hu22-HRP | Cloud-Clone |
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Monoclonal Antibody to Interferon Alpha 5 (IFNa5) | ||||
| MAG975Hu22 | Cloud-Clone | 100ul | 196 EUR | |
Monoclonal LRP-5/6 Antibody (Clone 1A12) | ||||
| APR08268G | Leading Biology | 0.1mg | 633.6 EUR | |
Monoclonal CD63 Antibody (clone AHN16.1/46-4-5), Clone: AHN16.1/46-4-5 | ||||
| AMM02309G | Leading Biology | 0.05mg | 580.8 EUR | |
Kallikrein 5 (KLK5) mouse monoclonal antibody, clone 193318 | ||||
| MO15028-500 | Origene Technologies GmbH | 500 µg | Ask for price | |
Interleukin 5 (IL5) Monoclonal Antibody (Human), FITC | ||||
| 4-MAA078Hu22-FITC | Cloud-Clone |
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5'-Nucleotidase, Ecto (NT5E) Monoclonal Antibody (Rat) | ||||
| 4-MAB250Ra21 | Cloud-Clone |
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Nephritogenic Monoclonal Antibody, Clone a84, 5 mg | ||||
| 70215 | Chondrex | 1 mg/ml x 5 ml | 3502 EUR | |
Nephritogenic Monoclonal Antibody, Clone b35, 5 mg | ||||
| 70225 | Chondrex | 1 mg/ml x 5 ml | 3502 EUR | |
Cd38 rat monoclonal antibody, clone NIMR-5, PE | ||||
| AM08041RP-N | Origene Technologies GmbH | 200 µg | Ask for price | |
Cd38 rat monoclonal antibody, clone NIMR-5, PE | ||||
| AM08041RP-S | Origene Technologies GmbH | 100 µg | Ask for price | |
Cd4 rat monoclonal antibody, clone RM4-5, FITC | ||||
| AM05638FC-N | Origene Technologies GmbH | 100 µg | Ask for price | |
Monoclonal Cytokeratin 5 Antibody, Clone: 3E2F1 | ||||
| APR15660G | Leading Biology | 0.1ml | 633.6 EUR | |
Macrophage Antigen Monoclonal antibody [Clone: LN-5] | ||||
| LN-5-100ug | Biologicals | 100 ug | 141.79 EUR | |
Macrophage Antigen Monoclonal antibody [Clone: LN-5] | ||||
| LN-5-1mg | Biologicals | 1 mg | 897.6 EUR | |
Macrophage Antigen Monoclonal antibody [Clone: LN-5] | ||||
| LN-5-500ug | Biologicals | 500 ug | 479.6 EUR | |
5'-Nucleotidase, Ecto (NT5E) Monoclonal Antibody (Human) | ||||
| 4-MAB250Hu21 | Cloud-Clone |
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Interferon Alpha 5 (IFNa5) Monoclonal Antibody (Human) | ||||
| 4-MAG975Hu22 | Cloud-Clone |
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Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) | ||||
| MAA684Hu21 | Cloud-Clone | 100ul | 243 EUR | |
Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) | ||||
| MAA684Hu22 | Cloud-Clone | 100ul | 235 EUR | |
Nonetheless, it is far-fetched that Only autoantibodies are fit for instigating immune system infections in people. For instance, microbes poisons, for example, lipopolysaccharide (LPS), Staphylococcal enterotoxin B (SEB), and M. arthritidis mitogen (MAM), play a synergistic impact with autoantibodies to type II collagen, and instigates serious joint inflammation in mice.