Collagen Antibody-Induced Arthritis (CAIA) has been generally utilized starting around 1998 when 4-clone mixed drink (Arthrogen-CIA arthritogenic monoclonal antibodies) units originally showed up.
To actuate steady joint inflammation all the more successfully in different mouse strains including CAIA low responder C57BL/6 mice, and an assortment of unusual knockout and transgenic mice with C57BL/6 (H-2b) or 129/Sv (H-2b) foundations, another 5-clone mixed drink units have been created by adding another clone to the 4-clone mixed drink.
The new 5-Clone CIAA creates quicker results: Typically serious joint pain is incited inside 24-48 hours rather than the a month expected to initiate CIA after inoculation with type II collagen. Not at all like the first CIA model, which requires a confined MHC haplotype, the new 5-Clone CAIA model is extensively pertinent and can prompt joint pain in practically all kinds of mice, including CIA-safe, T-cell lacking, quality knockout, and transgenic mice.
Usefully the new 5-Clone units offer phenomenal consistency meaning the seriousness of joint inflammation incited now straightforwardly connects to the portion of monoclonal immune response mixed drink, and more extreme and reliable joint inflammation can be prompted by expanding the portion of monoclonal counter acting agent mixed drink.
Hence, this model is great for concentrating on the neurotic job of individual quality items, cytokines, as well as screening and assessing mitigating specialists without impacts of complete or deficient Freund’s adjuvant, which emphatically influences the host’s resistant framework.
Established in 1987, AMS Biotechnology (AMSBIO) is perceived today as a main organization adding to the speed increase of disclosure through the arrangement of state of the art life science innovation items and administrations for innovative work in the clinical, nourishment, beauty care products and energy businesses.
The AMSBIO range incorporates expert antibodies, peptides and recombinant proteins. Likewise the organization can draw upon top to bottom mastery in extracellular lattices to give exquisite answers for concentrating on cell motility, relocation, intrusion and expansion.
Generally recognized as specialists in cell culture, AMSBIO accomplices with clients in fitting cell frameworks to improve screening results and inevitable guess. With a scope of atomic identification reagents, and a huge Biorepository the organization can likewise give tissue DNA, RNA, protein and microarray items.
Creature models have added to amazing advances in the comprehension of various human sicknesses. As important
as creature models are, a few disadvantages do exist. One such disadvantage originates from the various wellsprings of changeability which
can influence the result of the examinations.
In this manner, a pilot study is by and large suggested for first time clients of all creature models. A concise conversation of the 2 central matters of changeability will be made sense of underneath.
1. Mouse Vendors
The hereditary foundation of mice, even in a similar strain, will fluctuate from one merchant to another and can influence how the creatures
answer different reagents, along these lines affecting the consequences of your analysis (1). Along these lines, testing creatures from various
merchants utilizing a characterized convention is suggested prior to continuing with an enormous full-scale analyze.
2. Lodging Conditions
The microorganisms greenery is vital to the strength of the creature, including the legitimate working of the safe framework (1).
Subsequently, we suggest lodging creatures in Specific Pathogen Free (SPF) conditions instead of regular circumstances
to stay away from fluctuation brought about by microorganisms.
In general, exceptional thought of these primary concerns of fluctuation will help the analyst in finishing their trials with
less jumbling results.
CAIA sidesteps the prerequisite for host’s age of autoantibodies to type II collagen, consequently can be initiated in mice that try not to have CIA-helpless MHC-haplotypes (H-2q and H-2r) like different knockout or transgenic mice.
All kinds of mice, which are typical regarding mounting a provocative reaction including supplement enactment, ought to be
defenseless to CAIA.
Arthrogen-CIA 5-Clone Cocktail Kit - 10mg | ||||
| 53010 | Chondrex | 10 mg/ml x 1 ml | 1276.26 EUR | |
Arthrogen-CIA 5-Clone Cocktail Kit - 40mg | ||||
| 53040 | Chondrex | 10 mg/ml x 4 ml | 4758 EUR | |
Arthrogen-CIA 5-Clone Cocktail Kit - 100mg | ||||
| 53100 | Chondrex | 10 mg/ml x 10 ml | 11370 EUR | |
Monoclonal GFAP Antibody (clone GA-5), Clone: GA-5 | ||||
| APG03319G | Leading Biology | 0.05mg | 580.8 EUR | |
Monoclonal CCL5 / RANTES Antibody (clone 50013-5), Clone: 50013-5 | ||||
| AMM02131G | Leading Biology | 0.05ml | 580.8 EUR | |
Monoclonal FTO Antibody (clone 5-2H10), Clone: 5-2H10 | ||||
| AMM04626G | Leading Biology | 0.05ml | 580.8 EUR | |
Monoclonal ART3 Antibody (clone 3A2), Clone: 3A2 | ||||
| AMM01902G | Leading Biology | 0.05mg | 633.6 EUR | |
Monoclonal CIAS1 Antibody (monoclonal) (M01), Clone: 3B1 | ||||
| AMM03391G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal NKX2-5 Antibody (monoclonal) (M01), Clone: S3 | ||||
| AMM06706G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal NKX2-5 Antibody (monoclonal) (M02), Clone: S1 | ||||
| AMM06707G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CIAPIN1 Antibody (monoclonal) (M01), Clone: 5G8 | ||||
| AMM03390G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CD59 Antibody (clone MEM-43/5), Clone: MEM-43/5 | ||||
| AMM01725G | Leading Biology | 0.05mg | 580.8 EUR | |
Monoclonal ARTS-1 Antibody (monoclonal) (M01), Clone: 4H8 | ||||
| AMM03275G | Leading Biology | 0.1mg | 580.8 EUR | |
Nephritogenic Monoclonal Antibody, Clone 114, 5 mg | ||||
| 70205 | Chondrex | 1 mg/ml x 5 ml | 5976 EUR | |
Monoclonal CD11c FITC Monoclonal Antibody (Clone 3.9), Clone: 3.9 | ||||
| APR15331G | Leading Biology | 50 tests | 580.8 EUR | |
Monoclonal STX5 / Syntaxin 5 Antibody (clone 5A6), Clone: 5A6 | ||||
| AMM08041G | Leading Biology | 0.05mg | 633.6 EUR | |
Monoclonal CD28 FITC Monoclonal Antibody (Clone CD28.2), Clone: CD28.2 | ||||
| AMM00025G | Leading Biology | 0.05mg | 475.2 EUR | |
Monoclonal CD63 Antibody (clone AHN16.1/46-4-5), Clone: AHN16.1/46-4-5 | ||||
| AMM02309G | Leading Biology | 0.05mg | 580.8 EUR | |
Monoclonal Cytokeratin 5 Antibody, Clone: 1E1 | ||||
| AMM05823G | Leading Biology | 0.1ml | 580.8 EUR | |
Monoclonal LRP-5/6 Antibody (Clone 1A12) | ||||
| APR08268G | Leading Biology | 0.1mg | 633.6 EUR | |
Nephritogenic Monoclonal Antibody, Clone a84, 5 mg | ||||
| 70215 | Chondrex | 1 mg/ml x 5 ml | 5976 EUR | |
Nephritogenic Monoclonal Antibody, Clone b35, 5 mg | ||||
| 70225 | Chondrex | 1 mg/ml x 5 ml | 5976 EUR | |
Monoclonal Cytokeratin 5 Antibody, Clone: 3E2F1 | ||||
| APR15660G | Leading Biology | 0.1ml | 633.6 EUR | |
Monoclonal PRDX5 / Peroxiredoxin 5 Antibody (clone 12A), Clone: 12A | ||||
| AMM02102G | Leading Biology | 0.05ml | 580.8 EUR | |
Mouse Anti-CDV monoclonal antibody, clone 6-5 | ||||
| CABT-RM015 | Creative Diagnostics | 1 mg | 982.8 EUR | |
Monoclonal Aquaporin-5 Antibody, Clone: EPR3747 | ||||
| APG01972G | Leading Biology | 0.1ml | 633.6 EUR | |
Monoclonal GPX7 Antibody (clone 2704), Clone: 2704 | ||||
| AMM05213G | Leading Biology | 0.05mg | 580.8 EUR | |
Monoclonal KRT5 / CK5 / Cytokeratin 5 Antibody (clone 1E1), Clone: 1E1 | ||||
| APR17122G | Leading Biology | 0.05ml | 580.8 EUR | |
Monoclonal KRT5 / CK5 / Cytokeratin 5 Antibody (clone 2C2), Clone: 2C2 | ||||
| APR17123G | Leading Biology | 0.05mg | 580.8 EUR | |
Monoclonal KRT5 / CK5 / Cytokeratin 5 Antibody (clone 4H8), Clone: 4H8 | ||||
| APR17124G | Leading Biology | 0.05ml | 580.8 EUR | |
Monoclonal Ku (p70/p80)Mouse Monoclonal Antibody [Clone KU729], Clone: KU729 | ||||
| AMM00210G | Leading Biology | 0.5ml | 580.8 EUR | |
Monoclonal FTL Antibody (monoclonal), Clone: 4G7 | ||||
| AMM04622G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal Cytokeratin-5 Antibody, Clone: EPR1600Y | ||||
| APR15670G | Leading Biology | 0.1ml | 633.6 EUR | |
Monoclonal CST3 Antibody (monoclonal), Clone: 1H4 | ||||
| AMM03425G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal KRT5 / CK5 / Cytokeratin 5 Antibody (clone XM26), Clone: XM26 | ||||
| APR17125G | Leading Biology | 0.1ml | 580.8 EUR | |
Monoclonal F3 Antibody (monoclonal) (M01), Clone: 4G4 | ||||
| AMM03509G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal F8 Antibody (monoclonal) (M03), Clone: 1E9 | ||||
| AMM03510G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal F9 Antibody (monoclonal) (M01), Clone: 2C9 | ||||
| AMM03511G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal IF Antibody (monoclonal) (M01), Clone: 1B3 | ||||
| AMM03651G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal HD Antibody (monoclonal) (M02), Clone: 4G6 | ||||
| APR12332G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal HD Antibody (monoclonal) (M11), Clone: 3F1 | ||||
| APR12333G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal MB Antibody (monoclonal) (M04), Clone: 3F7 | ||||
| APR08355G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal MT Antibody (monoclonal) (M01), Clone: 2F2 | ||||
| APR08559G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal C3 Antibody (monoclonal) (M01), Clone: 5F9 | ||||
| APG03027G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal T Antibody (monoclonal) (M01), Clone: 5H8 | ||||
| AMM04163G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal T Antibody (monoclonal) (M02), Clone: 5C5 | ||||
| AMM04164G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal FH Antibody (monoclonal) (M09), Clone: 3E8 | ||||
| AMM04544G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal Fibulin 5 Antibody, Clone: 3F8D5; 7F8D5 | ||||
| AMM02617G | Leading Biology | 0.1ml | 580.8 EUR | |
Monoclonal FH Antibody (monoclonal) (M07), Clone: 5C12 | ||||
| AMM04543G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal APOB monoclonal antibody (M14), Clone: 3E5 | ||||
| APG01949G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal ECT2 monoclonal antibody (M01), Clone: 5D4 | ||||
| AMM04340G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal GDF5 monoclonal antibody (M06), Clone: 1F4 | ||||
| AMM04342G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal EDNRB monoclonal antibody (M01), Clone: 5H2 | ||||
| AMM07011G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal DCLK3 monoclonal antibody (M01), Clone: 2B1 | ||||
| APR15699G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal Fibulin 5 Antibody, Clone: 3F10A5; 3F8A12 | ||||
| APR11912G | Leading Biology | 0.1ml | 633.6 EUR | |
Monoclonal Cytokeratin 5/8 Antibody, Clone: SPM268 | ||||
| APR14554G | Leading Biology | 7 ml | 580.8 EUR | |
Monoclonal PDGFR Antibody (Clone # 275CT1), Clone: Clone # 275CT1 | ||||
| AMM00020G | Leading Biology | 0.05ml | 580.8 EUR | |
Rabbit Anti-HDAC7 monoclonal antibody, clone TE193-5 | ||||
| DCABH-5048 | Creative Diagnostics | 100 ul | 932.4 EUR | |
Rabbit Anti-PPARG monoclonal antibody, clone KG212-5 | ||||
| CABT-L880 | Creative Diagnostics | 100 ul | 932.4 EUR | |
Monoclonal TNFSF18 Antibody (monoclonal), Clone: 2E11 | ||||
| AMM04221G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal ACD Antibody (monoclonal) (M02), Clone: S1 | ||||
| AMM03232G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CA1 Antibody (monoclonal) (M02), Clone: M2 | ||||
| AMM03310G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CA1 Antibody (monoclonal) (M05), Clone: M1 | ||||
| AMM03311G | Leading Biology | 0.05mg | 580.8 EUR | |
Monoclonal AES Antibody (monoclonal) (M02), Clone: 10 | ||||
| APR14861G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CHP Antibody (monoclonal) (M02), Clone: S2 | ||||
| APR15427G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal AK1 Antibody (monoclonal) (M08), Clone: M1 | ||||
| APG01638G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CBS Antibody (monoclonal) (M01), Clone: 30 | ||||
| APG02460G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal LEP Antibody (monoclonal) (M02), Clone: M1 | ||||
| APR08190G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal SRF Antibody (monoclonal) (M03), Clone: 10 | ||||
| AMM04135G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal ESD Antibody (monoclonal) (M01), Clone: 10 | ||||
| AMM04445G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal GPT Antibody (monoclonal) (M04), Clone: M1 | ||||
| AMM05205G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CXCL2 monoclonal antibody (M21), Clone: 2D10 | ||||
| APR15647G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal MAGEA5 monoclonal antibody (M01), Clone: 6A5 | ||||
| AMM04341G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal NFAT5 monoclonal antibody (M02), Clone: 1H16 | ||||
| AMM04343G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal SDSL Antibody (clone M2), Clone: M2 | ||||
| AMR09854G | Leading Biology | 0.05mg | 633.6 EUR | |
Monoclonal NDN Antibody (monoclonal) (M02), Clone: 1B3 | ||||
| AMM06580G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal QDPR Antibody (monoclonal) (M02), Clone: M1 | ||||
| AMR09684G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal REN Antibody (monoclonal) (M01), Clone: 2H2 | ||||
| AMR09726G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal SDSL Antibody (monoclonal) (M02), Clone: M2 | ||||
| AMR09855G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal AFP Antibody (monoclonal) (M01), Clone: 1G7 | ||||
| AMM03247G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal APC Antibody (monoclonal) (M01), Clone: 3E3 | ||||
| AMM03266G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal C1D Antibody (monoclonal) (M03), Clone: 6H2 | ||||
| AMM03300G | Leading Biology | 0.05mg | 580.8 EUR | |
Monoclonal C4B Antibody (monoclonal) (M01), Clone: 2E4 | ||||
| AMM03305G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CA7 Antibody (monoclonal) (M06), Clone: 3B7 | ||||
| AMM03314G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CA8 Antibody (monoclonal) (M01), Clone: 1F7 | ||||
| AMM03315G | Leading Biology | 0.1mg | 580.8 EUR | |
Monoclonal CD7 Antibody (monoclonal) (M04), Clone: 1B8 | ||||
| AMM03349G | Leading Biology | 0.1mg | 580.8 EUR | |
Nonetheless, it is far-fetched that Only autoantibodies are fit for instigating immune system infections in people. For instance, microbes poisons, for example, lipopolysaccharide (LPS), Staphylococcal enterotoxin B (SEB), and M. arthritidis mitogen (MAM), play a synergistic impact with autoantibodies to type II collagen, and instigates serious joint inflammation in mice.